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TSH secretion shows a robust circadian regulation with an acrophase in the resting phase in humans and mice whereas the diurnal rhythms of THs are controversial as total and free THs show a shallow amplitude and often arrhythmicity 26,95,96,97

Although CB1 monotherapy weight loss data was not equivalent to GLP-1, it did show a 5.8% weight loss placebo reduction at 16 weeks

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Wadden TA, Tronieri JS, Sugimoto D, Lund MT, Auerbach P, Jensen C, et al

2018]Review Genetic disorders of GH action pathway